The Green Bay Packers (10-4) can lock up a playoff spot Monday when they host the banged-up New Orleans Saints (5-9) at Lambeau Field (8:15 p.m., ESPN). The Packers enter sitting seventh in the Super Bowl odds.

With the Saints potentially missing quarterback Derek Carr and running back Alvin Kamara due to injuries, oddsmakers made Green Bay an early 13.5-point favorite in the Monday Night Football odds. It's the final game of the week we're looking at in our NFL Week 16 predictions.

Our look at the Saints vs. Packers early picks and odds sees value in a New Orleans team that's still playing hard for interim head coach Darren Rizzi.

My early Saints vs. Packers prediction: Saints +13.5

NFL picks made Monday; odds subject to change. Our NEW NFL player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!

Prediction: Saints +13.5

Best odds: | Implied probability: 52.4%

There’s no secret that a lot of factors in this game are working against New Orleans.

Not only are the Saints playing outdoors in December at night in the frigid conditions of Lambeau Field, but they'll also potentially be without top running back Alvin Kamara (groin) and starting quarterback Derek Carr (concussion).

But all of those disadvantages are factored into the line, and I think a bit too heavily. New Orleans is playing inspired football under interim head coach Darren Rizzi, going 3-2 since the coaching change and nearly upsetting the Washington Commanders last week. Meanwhile, Green Bay is essentially locked into a wild-card spot and could already be looking ahead to a Week 17 clash with the division-rival Minnesota Vikings.

I’ll grab the +13.5 line now with a Saints team that hasn’t allowed more than 21 points in its last five games. Then I'll cross my fingers that Carr or Kamara (or both) are able to suit up for Monday night.

Don't miss our guide for how to bet on NFL or this week's best sportsbook promos.

Saints vs. Packers live odds

See the NFL odds from our best NFL betting sites for every Week 16 game.

Moneyline

• Packers best odds: -800 via DraftKings | Implied probability: 88.9%
• Saints best odds: +575 via BetMGM | Implied probability: 14.8%

There wasn’t a significant discrepancy among the top NFL prop betting sites when it came to the early moneyline for this game. The -800 offering at DraftKings and Caesars is the best price on the Packers, while BetMGM’s +575 leads to the largest potential return on the underdog Saints.

Spread

• Packers best odds: -13.5 (-110) via FanDuel
• Saints best odds: +13.5 (-110) via DraftKings

Green Bay hasn't been a two-touchdown favorite since 2012, while the Saints haven’t been an underdog with the same line since 1998. Those trends will continue if news breaks that either Carr or Kamara will be back, so be sure to monitor injury updates throughout the week.

Over/Under

• Over best odds: 42 (-108) via DraftKings
• Under best odds: 42 (-110) via BetMGM

The total was sitting at 42 across the board at our best sports betting sites Monday night, although DraftKings offered Over bettors a bit of a discount with its -108 price.

Caesars, FanDuel, BetMGM, and other top NFL parlay betting sites featured balanced -110 vig on both sides of the total. Any new information about New Orleans’ offensive injuries would certainly impact the total too, especially if Carr can return.

How to watch Saints vs. Packers

• When: Monday, Dec. 23
• Kickoff: 8:15 p.m. ET
• Where: Lambeau Field, Green Bay, WI
• How to watch: ESPN
• Weather: 24 degrees, 0% chance of precipitation, wind 8-mph SSW
• Favorite: Packers (-13.5 via Caesars)

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