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Iowa State guard Curtis Jones shoots over Marquette forward Royce Parham. We're backing Jones in our Kansas vs. Iowa State prediction. — Pictured: Iowa State guard Curtis Jones shoots over Marquette forward Royce Parham. Photo by Reese Strickland-Imagn Images.

In a showdown between the two highest-ranked teams in the Big 12, Iowa State (14-1) hosts Kansas (12-3) on Wednesday at 7 p.m. ET (ESPN2) from Hilton Coliseum in Ames, Iowa.

Our Kansas vs. Iowa State prediction and odds expect the Cyclones to show why they're getting the third-shortest March Madness odds
While Iowa State doesn't feature any player in the Wooden Award odds race, the team boasts one of the nation's deepest rosters
The Jayhawks are a 6.5-point road underdog at our March Madness betting sites due to their inconsistent offense

Kansas vs. Iowa State predictions today

College basketball picks based on the odds from our best March Madness betting sites.

Against the spread pick: Iowa State -6.5 (-110 via Caesars) vs. Kansas ⭐⭐⭐
My best pick: Curtis Jones Over 2.5 made 3-pointers (-115 via bet365) ⭐⭐⭐⭐

Kansas vs. Iowa State ATS prediction

Iowa State to cover the spread: -6.5 ⭐⭐⭐

Notching a seven-plus-point win against the No. 9 team in the country won't be easy, but T.J. Otzelberger's squad matches up well with Kansas. The Jayhawks' offense has been troublesome all season while ranking just 31st in adjusted offensive efficiency, according to .

Even with the likes of Hunter Dickinson and Zeke Mayo, Kansas is just 124th in the country in points per game (77.3), and the team is one-dimensional with its inability to shoot from behind the arc. The Jayhawks are 266th in threes per game (6.9) and 219th in 3-point percentage (33.1%).

That will allow Iowa State's ferocious defense - which ranks fifth in the country in D-Rate, according to - to focus on defending inside the arc. Even with a lack of size at the five spot to slow Dickinson, the Cyclones' offensive efficiency should lead to them doing enough against this stout Kansas defense to cover.

Iowa State is 10th in the country in points per game (86.2) and field-goal percentage (50.1%), and the team boasts four players who rank in the top 20 in the Big 12 in OBPR. Kansas features just one in Dickinson.

If the Cyclones cover for the fifth time in six games, a $10 bet pays a $9.09 profit.

Best odds: -110 via Caesars | Implied probability: 52.38%

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Best Kansas vs. Iowa State pick

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Curtis Jones Over 2.5 made 3-pointers ⭐⭐⭐⭐

A team's leading scorer rarely comes off the bench, but that's the case with Iowa State and Curtis Jones. The former All-MAC star at Buffalo has been taking a big step in his second season with Otzelberger's program, and he sits third in the Big 12 in points per game (17.3).

His shooting from deep has been particularly impressive, and he ranks top 10 in the conference in both threes per game (2.7) and 3-point percentage (39%). That's going to come in handy against a tough Jayhawks defense, though one that's a more susceptible unit on the perimeter this season. The team is allowing the 31st-fewest twos per game (14.9) but the 87th-fewest threes (6.8).

Jones has also been hot lately while going 6-for-14 (42.9%) from behind the arc in his last two games, and he's already hit three-plus threes in nine of 15 outings this season (60%). If he can do it again, a $10 bet pays an $8.70 profit.

Best odds: -115 via bet365 | Implied probability: 53.49%

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Live Kansas vs. Iowa State odds

See all of this week's college basketball odds and NCAAB scores.

Kansas vs. Iowa State opening odds

Spread: Kansas +6 (-110) | Iowa State -6 (-110)
Over/Under: Over 144 (-110) | Under 144 (-110)
Moneyline: Kansas +205 | Iowa State -250

Kansas vs. Iowa State game info

When: Wednesday, Jan. 15
Tipoff: 7 p.m. ET
Where: Hilton Coliseum (Ames, Iowa)
How to watch: ESPN2
Favorite: Iowa State -6.5 (-110 via Caesars)

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Written By:
Rob Paul

Rob is a Publishing Editor at Sportsbook Review. He’s been with the team since early 2024, with this being his first full-time role in the sports betting industry. Before joining kansnzkz.shop, he contributed to various sports outlets, including FanSided and Pro Football Network. During that period, he spent five years working full-time as a local community journalist, after attending Durham College for journalism and Wilfrid Laurier University for history. He previously hosted an NFL draft and college football-focused podcast where he had the opportunity to interact with future NFL players such as Maxx Crosby and Quinn Meinerz. Rob has spent multiple years working as a freelance podcast producer for numerous sports-related podcasts while making guest appearances on several college football shows. He’s also made guest appearances on SportsTalk Mississippi on several occasions to talk all things NFL draft. Rob values the way sports betting acts as a catalyst for telling stories and growing interest in certain sports, particularly FCS football, WNBA, and mid-major college basketball. He’s always been drawn to the more obscure teams and conferences in major college sports, but most of all, Rob loves using stats to find the best player props to back.