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Ohio State Buckeyes quarterback Will Howard makes a shovel pass as we make our Indiana vs. Ohio State early picks. — Ohio State Buckeyes quarterback Will Howard makes a shovel pass during the second half of the NCAA football game against the Northwestern Wildcats. Photo by: Adam Cairns/Columbus Dispatch / USA TODAY NETWORK via Imagn Images.

Indiana’s quest for perfection meets its biggest obstacle of the season in Week 13 when the Hoosiers visit the Ohio State Buckeyes.

My Indiana vs. Ohio State early predictions and odds dig into how the public will play this pivotal contest. Kickoff from Ohio Stadium in Columbus, Ohio, is slated for noon ET (FOX) on Saturday.

This is a major showdown between two of the top contenders by the college football championship odds and the college football playoff odds.

Four teams remain in the hunt for the Big Ten title game: Oregon, Indiana, Ohio State, and Penn State. As such, the stakes for this regular season showdown could not be any higher, with the Hoosiers looking to win in Columbus for the first time since 1987.

The below picks are part of our college football Week 13 predictions.

We also continued to track this game with our Indiana vs. Ohio State prediction and Indiana vs. Ohio State player prop bets.

My early Indiana vs. Ohio State prediction

College football picks made Monday; odds subject to change. Our NEW college football player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!

Prediction: Over 51.5

Best odds: | Implied probability: 52.38%

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Indiana (43.9 points per game) and Ohio State (37.8 points per game) rank second and 12th, respectively, on the NCAA’s scoring offense list. They’re also seventh and first in points allowed per game, which makes this total tricky to play. Neither team has seen an offense as explosive as the other to date, though.

History tells us this matchup will be high-scoring. Twelve of the last 13 meetings between the Buckeyes and Hoosiers have seen the scoreboard light up for more than 52 total points. It’s not been as one-sided as many would expect given Ohio State’s recent dominance either, Indiana has proven it can score in this contest.

Only four teams have gone Over more than the Hoosiers this season. Indiana leans 7-3 to the Over, whereas the Buckeyes are 4-6 to the Under. DraftKings offers the lowest total on the market at 51.5, so with the trends on our side, we’ll ride with the Over at -110. Nearly 70% of public tickets on the total at BetMGM agree with us, so it’s best to place your wager before the line increases throughout the week.

Don't miss our guide for how to bet on college football or this week's best sportsbook promos.

Indiana vs. Ohio State live odds

See the college football odds from our best college football betting sites for every Week 13 game.

Moneyline

Ohio State best odds: -400 via BetMGM | Implied probability: 80%
Indiana best odds: +350 via bet365 | Implied probability: 22.22%

This is one of the rare times when an unbeaten team has serious betting value. Oddsmakers are giving the Hoosiers around a 22-25% chance to win, whereas ESPN Analytics lists them at 26.7%. The Buckeyes have won the last 28 meetings straight up, which partly explains why the best odds available for the hosts are -400 with BetMGM.

Spread

Ohio State best odds: -11 (-110) via Caesars
Indiana best odds: +12 (-110) via DraftKings

BetMGM tells us that the public is refraining from betting on Indiana to win the matchup outright, but it loves the Hoosiers to cover the double-digit spread. This means you should take advantage of DraftKings’ 12-point spread (-110) as soon as possible. It would benefit Ohio State bettors to be patient and see if the line closes closer to 10 points before kickoff.

Over/Under

Over best odds: 51.5 (-110) via DraftKings
Under best odds: 52.5 (-110) via BetMGM

Most sportsbooks seem to have settled on a 52 or 52.5-point total for this contest. DraftKings is the lone sportsbook with a total of 51.5 points, which, as we alluded to above, is our favorite early lean for this contest.

How to watch Indiana vs. Ohio State

When: Saturday, Nov. 23
Kickoff: Noon ET
Where: Ohio Stadium (Columbus, Ohio)
How to watch: FOX
Weather: 41 degrees, 23% chance of precipitation, wind 14 mph W
Favorite: Ohio State -11.5 (-105 via BetMGM)

College football betting odds pages

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Written By:
Gabe Henderson

Gabe Henderson is a sports betting writer from Houston, Texas. He graduated from Louisiana State University in 2022 with a bachelor's degree in Mass Communication. Gabe developed an interest in sports betting while in college due to its legalization in Louisiana. He turned his passion into a career shortly after, joining The Advocate/NOLA.com as a Sports Betting Content Coordinator, where he spent two years. Gabe wore many hats before graduating as he led FanSided's coverage of Chelsea FC as a Site Expert with "The Pride of London." He was also the Editor-in-Chief of the LSU Gumbo Yearbook for two years. Gabe became a part of the kansnzkz.shop team in late 2024. He brings with him an extensive knowledge of many sports, including — but not limited to — NFL, NCAA, MLB, NBA, soccer, and UFC. Sports betting has not yet been legalized in Gabe's home state of Texas, so he frequently takes trips to Louisiana when he has the itch to place futures. Outside of work, Gabe considers himself an old head as he used an AOL email account until 2022 and still collects vinyl records.