The Colorado Buffaloes look to keep their hopes for a Big 12 Championship and subsequent College Football Playoff berth alive when they face the Kansas Jayhawks as road favorites on Saturday.

• Colorado's four-game winning streak is tied for the longest active winning streak of any Big 12 team
• If the Buffaloes - the favorite - win their two remaining games against Kansas and Oklahoma State, they will clinch a spot in the Big 12 Championship Game
• Kansas looks for its third straight win over a ranked team in as many weeks after upsets of Iowa State and BYU

Our Colorado vs. Kansas prediction, part of our college football Week 13 predictions, acknowledges how much better the Jayhawks are than their 4-6 record indicates. However, I feel the Buffaloes have too much talent for Kansas to pull a fourth straight upset.

Colorado is a 2.5-point to 3.5-point road favorite in a game with an O/U of 59.5. Kickoff from GEHA Field at Arrowhead Stadium is set for 3:30 p.m. ET, airing on FOX.

We also broke down this game as part of our college football Week 13 expert picks and in our Colorado vs. Kansas player props.

Colorado vs. Kansas prediction & best bet

College football picks based on the odds from our best college football betting sites. Odds subject to change.

• Against the spread pick: Colorado -2.5 () vs. Kansas ⭐⭐⭐⭐
• My best bet: Devin Neal Under 96.5 rushing yards () ⭐⭐⭐⭐

Colorado vs. Kansas ATS prediction: Week 13

Colorado to cover the spread: -2.5 ⭐⭐⭐⭐

Best odds: -115 via DraftKings | Implied probability: 53.49%

Colorado’s massive improvements

Last week, we nailed our prediction that Kansas would cover and upset previously undefeated BYU.

But much of that prediction was centered around how inferior the Cougars' metrics were compared to their 9-0 record. Colorado, on the other hand, is a team that continually improves.

Colorado’s pass protection was a big reason it did not get the most out of its skill position players en route to a 4-8 record last year (1-8 in Big 12 play), as Shedeur Sanders was constantly running for his life.

However, from Week 7 to the start of last week, the Buffaloes ranked fifth among Power Four teams in Pass Blocking Grade, third in pressure percentage allowed, ninth in knockdown percentage, and was tied for 16th in sacks allowed.

In that span, offensive linemen like Tyler Brown, Justin Mayers, and Kareem Harden earned pass-blocking grades above 80, per PFF. And while the team leaned on true freshman center Cash Cleveland on the road against Texas Tech in his first start, he turned in a respectable 72.1 overall PFF grade.

The Buffaloes dominated Utah

Colorado beat Utah 49-24 last week, and there were many positive takeaways from the victory.

The Buffaloes did well to limit a stout Utes front to three sacks, especially since Utah blitzes at one of the highest rates in the country.

Arguably the most impressive thing about the 25-point victory was that Utah entered the game with a 77.0 run-blocking grade, and Micah Bernard ranked 11th in yards after contact among Power Four tailbacks. However, the Buffaloes limited him to 20 yards on 11 carries, and Utah managed just 31 rushing yards on 30 attempts.

Colorado is a cover machine

The Buffaloes have covered the spread in their last eight games and won seven consecutive games against unranked opponents.

As favorites under Deion Sanders, Colorado is 9-1 straight up. It is also good that the Buffaloes are not bigger favorites, as they are 1-3 ATS as favorites of eight or more points under Sanders.

Sanders’ Colorado teams are now 15-6-1 ATS (71.4% cover rate). Per Evan Abrams, that makes Sanders’ ATS cover percentage the second-highest among all coaches (min. 20 games) since 2000.

I am rushing to the betting windows to grab the lone remaining -2.5 available at DraftKings, as other top sports betting sites like FanDuel have already moved to -3.5. As long as I can back the Buffaloes at less than a field goal, that wager will get four stars of confidence.

Colorado vs. Kansas best bet

Our NEW college football player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!

Devin Neal Under 96.5 rushing yards ⭐⭐⭐⭐

Best odds: -114 via FanDuel | Implied probability: 53.27%

Neal ranks fifth in the Big 12 with 926 rushing yards and has gone over 100 yards rushing six times this year.

However, Neal has also been held to 71 or fewer rushing yards in four of the last six games, and the Jayhawks did some  because of injuries last week.

Neal faces a Colorado defense that, prior to holding Utah to 31 rushing yards, ranked 39th in run defense - a vast improvement from last season's No. 122 ranking.

Coach Prime can stack the box with a secondary ranked 23rd in coverage grade, led by Heisman Trophy odds hopeful Travis Hunter. With the Buffaloes cornerbacks playing on an island, I expect Neal to go under this projected total.

Under backers are getting tremendous value making this wager at FanDuel, as competing sportsbooks like bet365 and Caesars have Neal’s O/U set at 89.5.

Through FanDuel’s -114 odds, a $10 winning wager would net $8.77 in profits.

Colorado vs. Kansas odds

See all of this week's college football odds and NCAAF scores.

Colorado vs. Kansas opening odds:

• Colorado: -2.5 (-110 via BetMGM)
• Kansas: +2.5 (-110 via BetMGM)

Colorado vs. Kansas game info

• When: Saturday, Nov. 23
• Kickoff: 3:30 p.m. ET
• Where: GEHA Field at Arrowhead Stadium (Kansas City, Mo.)
• How to watch: FOX
• Weather: 55 degrees, 10% chance of precipitation, wind 9 mph SE
• Favorite: Colorado -3 (-105 via BetMGM)

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